Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth

Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth.

Tbx4 is a crucial gene in the initiation of hindlimb development and has been reported as a determinant of hindlimb identity and a presumptive direct regulator of Fgf10 in the limb. Using a conditional allele of Tbx4, we have ablated Tbx4 function before and after limb initiation. Ablation of Tbx4 before expression in the hindlimb field confirms its requirement for limb bud outgrowth. However, ...

متن کامل

Pitx1 is necessary for normal initiation of hindlimb outgrowth through regulation of Tbx4 expression and shapes hindlimb morphologies via targeted growth control.

The forelimbs and hindlimbs of vertebrates are morphologically distinct. Pitx1, expressed in the hindlimb bud mesenchyme, is required for the formation of hindlimb characteristics and produces hindlimb-like morphologies when misexpressed in forelimbs. Pitx1 is also necessary for normal expression of Tbx4, a transcription factor required for normal hindlimb development. Despite the importance of...

متن کامل

21-P040 Tbx4 does not rescue limb-type specification in Pitx1−/− mouse

Vertebrates have two pairs of morphologically distinct appendages, the forelimbs and the hindlimbs. Although the mechanisms necessary for limb outgrowth and polarity are becoming fairly well-understood little is known about how limb-type identity is regulated. The homeobox containing transcription factor Pitx1 expressed in hindlimb bud mesenchyme and has been shown to be involved in limb-type d...

متن کامل

21-P042 Receptor protein tyrosine phosphatases as potential regulators of neurotrophin receptors in developing sensory neurons

Vertebrates have two pairs of morphologically distinct appendages, the forelimbs and the hindlimbs. Although the mechanisms necessary for limb outgrowth and polarity are becoming fairly well-understood little is known about how limb-type identity is regulated. The homeobox containing transcription factor Pitx1 expressed in hindlimb bud mesenchyme and has been shown to be involved in limb-type d...

متن کامل

21-P041 Identification of ligand-specific mechanisms of JAK/STAT signalling regulation

Vertebrates have two pairs of morphologically distinct appendages, the forelimbs and the hindlimbs. Although the mechanisms necessary for limb outgrowth and polarity are becoming fairly well-understood little is known about how limb-type identity is regulated. The homeobox containing transcription factor Pitx1 expressed in hindlimb bud mesenchyme and has been shown to be involved in limb-type d...

متن کامل

Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth

نویسندگان

چکیده

برای دانلود باید عضویت طلایی داشته باشید

منابع مشابه